925617-80-7Relevant academic research and scientific papers
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands
Ghosh, Arun K.,Takayama, Jun,Kassekert, Luke A.,Ella-Menye, Jean-Rene,Yashchuk, Sofiya,Agniswamy, Johnson,Wang, Yuan-Fang,Aoki, Manabu,Amano, Masayuki,Weber, Irene T.,Mitsuya, Hiroaki
, p. 4903 - 4909 (2015)
We describe the design, synthesis and biological evaluation of a series of novel HIV-1 protease inhibitors bearing isophthalamide derivatives as the P2-P3 ligands. We have investigated a range of acyclic and heterocyclic amides as the extended P2-P3 ligan
11a-Methano-TXA compounds
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, (2008/06/13)
The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.
