925672-53-3Relevant articles and documents
β-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent δ opioid antagonists
Tóth, Géza,Ioja, Eniko,T?mb?ly, Csaba,Ballet, Steven,Tourwé, Dirk,Péter, Antal,Martinek, Tamás,Chung, Nga N.,Schiller, Peter W.,Benyhe, Sándor,Borsodi, Anna
, p. 328 - 333 (2007/10/03)
The opioid peptide TIPP (H-Tyr-Tic-Phe-Phe-OH, Tic: 1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid) was substituted with Dmt (2′,6′-dimethyltyrosine) and a new unnatural amino acid, β-MeCha (β-methylcyclohexylalanine). This double substitution led to a
