925700-75-0Relevant academic research and scientific papers
NEW CHEMICAL COMPOUNDS
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Page/Page column 69-70, (2008/12/08)
The present invention provides compounds of formula (I) having muscarinic M3 receptor and β-adrenergic receptor modulating activity; processes for their preparation and their use in therapy; wherein A, R1, R2, R3 and Rsup
BICYCLOR[2.2.1]HEPT-7-YLAMINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR MODULATORS
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Page/Page column 17, (2008/12/08)
Representatives of compounds of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.
BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES
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Page/Page column 47, (2010/11/25)
Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group-N(R12)-;(i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group-R5,-Z-Y-R5-Z-NR9R10;-Z-CO-NR9R 10;-Z-NR9-CO-R5; or-Z-CO2H; and R3 is a lone pair,or C1-C6-aIkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R1 and R 3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group-R5,-Z-Y-R5,-Z-NR9R10,-Z-CO-NR9R10,-Z-NR9-CO-R5 , or-Z-CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R 1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group-Y-R5,-Z-Y-R5,-Z-NR9R 10;-Z-CO-NR9R10;-Z-NR9-CO-R 5; or-Z-CO2H and R3 is a lone pair, or C 1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; R 4 is a group of formula (a), (b), (c) or (d); is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.
