92571-71-6Relevant academic research and scientific papers
Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
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, (2008/06/13)
Novel compound of the formula: STR1 wherein R1 is a pyridyl group; R2 is a phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl group which may have as a substituent a lower alkoxy, a lower alkyl, a halogen, trifluoromethyl, a lower alkenyl or methylenedioxy; R3 is hydrogen, benzyl or a lower alkyl; one of R4 and R5 is hydrogen or a lower alkyl, and the other is an aryloxy, or lower aliphatic hydrocarbon, an alicyclic hydrocarbon having not more than 6 carbon atoms or an aromatic group which may have a substituent, or a group represented by the formula, --S(O)m --R6 (in which R6 is phenyl or a lower alkyl group; m is an integer of 0 to 2), or R4 and R5 each combine with the other to represent one alkylene group; n is an integer of 2 to 6, or a pharmaceutically acceptable salt thereof has a selective inhibitory action on bio-synthesis of thromboxane A2 (TXA2) and an effect of enhancing the production of prostaglandin I2 (PGI2), and can be used in mammals for to prevention and treatment of arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardian infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).
Thromboxane Synthetase Inhibitors (TXSI). Design, Synthesis, and Evaluation of a Novel Series of ω-Pyridylalkenoic Acids
Kato, Kaneyoshi,Ohkawa, Shigenori,Terao, Shinji,Terashita, Zen-ichi,Nishikawa, Kohei
, p. 287 - 294 (2007/10/02)
A novel series of ω-pyridylalkenoic acids has been prepared by applying the Wittig reaction.Modifications were made in the ω-aryl moiety, the alkylene chain length, the α-methylene group adjacent to the carbonyl group, and the carboxyl group in the molecu
