92587-67-2Relevant academic research and scientific papers
GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE
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Paragraph 0151-0153; 0184, (2021/04/23)
The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.
Photo-induced sonogashira C-C coupling reaction catalyzed by simple copper(I) chloride salt at room temperature
Sagadevan, Arunachalam,Hwang, Kuo Chu
supporting information, p. 3421 - 3427 (2013/02/22)
The conventional thermal Sonogashira C-C coupling reaction requires the use of a palladium catalyst and a large amount of ligands. Although there were a few reports describing the use of inexpensive metal catalysts, such as, copper (Cu), iron (Fe), and nickel (Ni), for replacement of palladium (Pd) in the Sonogashira reactions, it was later questioned that the observed effects were due to ppb levels contamination of Pd present in the reagents used in the reactions. Herein, we report that simple copper(I) chloride (CuCl) salt, in the absence of Pd and ligands, can catalyze the Sonogashira reaction with high yields (80-99%) under blue LED light irradiation at room temperature. Control experiments show that no cross-coupling product was formed, when palladium(II) chloride (PdCl2) was used to replace CuCl as a catalyst. A series of electron-rich and electron-poor substituted aryl halides (bromides and iodides) as well as aryl- and alkylacetylenes are examined and the reaction mechanism is discussed.
Effects of linker elongation in a series of N-(2-benzofuranylmethyl)- N′-(methoxyphenylalkyl)piperazine σ1 receptor ligands
Moussa, Iman A.,Banister, Samuel D.,Akladios, Fady N.,Chua, Sook Wern,Kassiou, Michael
supporting information; experimental part, p. 5707 - 5710 (2011/10/18)
In our continued exploration of disubstituted piperazine derivatives as sigma (σ) receptor ligands with central nervous system (CNS) activity, a series of N-(2-benzofuranylmethyl)-N′-(methoxyphenylalkyl)piperazines (16-21 and 26-31) were synthesized, anti
