92587-93-4Relevant academic research and scientific papers
A chiral template-driven synthesis of a 3′-deoxy-3′-18F-fluorothymidine precursor
Dey, Papiya,Ajish Kumar,Sharma, Anubha,Chattopadhyay, Subrata
, p. 1457 - 1462 (2018)
An asymmetric synthesis of a 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the 18F-FLT precursors wherein the expensive starting material, thymidine was used.
