925891-74-3

Basic information

• Product Name: N-Octadecyl-N'-propyl-sulfamide
• Synonyms: N-Octadecyl-N'-propyl-sulfamide;N-(propylsulfamoyl)octadecan-1-amine
• CAS NO: 925891-74-3
• Molecular Formula: C21H46N2O2S
• Molecular Weight: 390.66714
• Mol File: 925891-74-3.mol

Chemical Properties

• Appearance: /
• Solubility: ≤0.2mg/ml in ethanol
• CAS DataBase Reference: N-Octadecyl-N'-propyl-sulfamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Octadecyl-N'-propyl-sulfamide(925891-74-3)
• EPA Substance Registry System: N-Octadecyl-N'-propyl-sulfamide(925891-74-3)

Safety Data

• Hazardous Substances Data: 925891-74-3(Hazardous Substances Data)

Usage

references

[1]. cano c, pavón j, serrano a, et al. novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and pparalpha activation. j med chem. 2007 jan 25;50(2):389-93.[2]. fu j1, gaetani s, oveisi f, et al. oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor ppar-alpha. nature. 2003 sep 4;425(6953):90-3.

Upstream product

• 10305-42-7 N-propylsulfamoyl chloride 
• 124-30-1 1-aminooctadecane 

Relevant articles and documents

Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARα activation

Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARα) activators. Additionally, the anorexic effects of the new compounds have been studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N′-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPARα.

Efficient synthesis of unsymmetrical sulfamides from sulfamic acid salts by activation with triphenylphosphine ditriflate

A general approach to prepare unsymmetrical sulfamides is described. This method relies on the activation of sulfamic acid salts with triphenylphosphine ditriflate, and subsequent trapping by a nucleophilic amine. This strategy improves access to N-octade

ACYCLIC SULFAMIDE DERIVATIVES

The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.