925922-96-9 Usage
Molecular weight
194.19 g/mol
Type of compound
Synthetic chemical compound
Functional group
Ketone derivative
Research and pharmaceutical applications
Used in the development of new medications and drugs
Potential pharmacological and biological activities
Known for its effects on the central nervous system
Scientific research and product development
Exhibits unique chemical and physical properties
Structural features
Contains a 4-fluoro-2-methoxymethoxy-phenyl group attached to an ethanone (acetophenone) moiety
Solubility
Likely soluble in organic solvents such as ethanol, methanol, and acetone
Stability
Stable under normal laboratory conditions, but should be stored away from heat, light, and moisture to prevent degradation
Safety precautions
Handle with care, using appropriate personal protective equipment (PPE) such as gloves and eye protection
Purity
Typically synthesized with high purity for research purposes, but may contain trace impurities depending on the synthesis method
Analytical techniques
Can be characterized using techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and infrared (IR) spectroscopy
Synthesis
Can be synthesized through various methods, such as the reaction of a suitable aryl halide with an appropriate nucleophile, followed by protection of the hydroxyl group and subsequent ketone formation
Reactivity
May undergo reactions typical of ketones, such as nucleophilic addition, reduction, and oxidation, as well as reactions specific to the fluoro and methoxymethoxy substituents.
Check Digit Verification of cas no
The CAS Registry Mumber 925922-96-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,5,9,2 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 925922-96:
(8*9)+(7*2)+(6*5)+(5*9)+(4*2)+(3*2)+(2*9)+(1*6)=199
199 % 10 = 9
So 925922-96-9 is a valid CAS Registry Number.
925922-96-9Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54
Kobayashi, Toshitake,Sasaki, Satoshi,Tomita, Naoki,Fukui, Seiji,Kuroda, Noritaka,Nakayama, Masaharu,Kiba, Atsushi,Takatsu, Yoshihiro,Ohtaki, Tetsuya,Itoh, Fumio,Baba, Atsuo
experimental part, p. 3841 - 3859 (2010/08/06)
GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure-activity relationship studies led to compound 9l with an IC50 value of 3.7 nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay.
