925923-78-0

Basic information

• Product Name: 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile
• Synonyms: 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile
• CAS NO: 925923-78-0
• Molecular Weight: 390.398
• Mol File: 925923-78-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile(925923-78-0)
• EPA Substance Registry System: 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile(925923-78-0)

Safety Data

• Hazardous Substances Data: 925923-78-0(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 133101-42-5 1-<2-(methoxymethoxy)phenyl>-1-propanone 
• 109-77-3 malononitrile 

Downstream Products

• 925923-79-1 N-{3-cyano-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide 

Relevant articles and documents

Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54

GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure-activity relationship studies led to compound 9l with an IC50 value of 3.7 nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay.