925940-94-9

Upstream product

• 925940-93-8 3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-(3-iodo-phenyl)-isoxazole 
• 557-21-1 dicyanozinc 

Downstream Products

• 925940-89-2 3-[3-(1-hydroxy-ethyl)-isoxazol-5-yl]-benzonitrile 

Relevant academic research and scientific papers

Substituted piperazines as metabotropic glutamate receptor antagonists

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

MGluR5 modulators VI

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.