926004-74-2

Usage

Class

Pyrrolopyridines

Structure

A pyrrole ring fused to a pyridine ring

Iodine atom

At the fourth position

Methoxy group

At the fifth position

Potential applications

Medicinal chemistry and drug development

Biological activity

May exhibit biological activity useful for the treatment of various diseases

Molecule of interest

For further research and potential pharmaceutical development

Upstream product

• 1020056-72-7 4-chloro-5-methoxy-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF

Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

CHEMICAL COMPOUNDS

The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.