92614-59-0 Usage
Description
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell-permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
Uses
Different sources of media describe the Uses of 92614-59-0 differently. You can refer to the following data:
1. A cell permeable derivative of GSH
2. Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
3. Glutathione reduced ethyl ester has been used:to increase intracellular glutathione levels in mouse fibroblast L929 cellsas a medium supplement in Spodoptera frugiperda (Sf)9 cellsto evaluate its effect on lipid peroxidation after spinal cord injury
Biochem/physiol Actions
Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.
Check Digit Verification of cas no
The CAS Registry Mumber 92614-59-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,6,1 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92614-59:
(7*9)+(6*2)+(5*6)+(4*1)+(3*4)+(2*5)+(1*9)=140
140 % 10 = 0
So 92614-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H21N3O6S/c1-2-7(22)10(11(19)14-5-9(17)18)15-8(16)4-3-6(13)12(20)21/h6-7,10,22H,2-5,13H2,1H3,(H,14,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7?,10-/m0/s1
