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Usage

Uses

Used in Pharmaceutical Industry:
2-(pyridin-4-ylmethoxy)benzoic acid is used as a nonsteroidal anti-inflammatory drug (NSAID) for its ability to inhibit the production of prostaglandins, which are molecules that play a role in pain and inflammation.
Used in Medicinal Chemistry:
2-(pyridin-4-ylmethoxy)benzoic acid is used as a starting material for the synthesis of various pharmacologically active molecules, contributing to drug discovery research. Its structural features, including the pyridine group, allow it to interact with specific biological targets, potentially influencing the compound's pharmacological profile and making it a valuable asset in the development of new therapeutic agents.

Downstream Products

• 1036967-17-5 C₁₉H₁₅ClN₂O₂ 

Relevant academic research and scientific papers

Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity

We found 4-pyridylmethylthio derivative 1 to be very effective in using antiangiogenesis activity to prevent proliferation of HUVECs (Human Umbilical Vein Endothelial Cells), which was induced by vascular endothelial growth factor (VEGF). Compound 1 was equally effective in inhibiting VEGF receptor2 tyrosine kinase (KDR, IC50 = 26 nM). We deduced that the inhibition was the result of binding the catalytic domain of VEGF receptor2 tyrosine kinase in a similar fashion to both phthalazine derivative PTK787 2 and anthranylamide derivative AAL993 3. In this report, we will describe the conformational analyses, from ab initio MO calculation and X-ray crystallographic analyses, of compound 1 and the analogs, which include non-active 9, all in comparison with 2 and 3. The conformation-activity relationships suggest that a nonbonded intramolecular interaction between the sulfur and the carbonyl oxygen of 1 was very important in inhibiting KDR.