926221-17-2Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents
Monforte, Anna-Maria,Logoteta, Patrizia,Ferro, Stefania,Luca, Laura De,Iraci, Nunzio,Maga, Giovanni,Clercq, Erik De,Pannecouque, Christophe,Chimirri, Alba
experimental part, p. 5962 - 5967 (2009/12/24)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have become very important components in the antiretroviral combination therapies used to treat HIV. Recently, our group identified some 1,3-dihydrobenzimidazol-2-one derivatives and their sulfones as a potent and novel class of NNRTIs. We herein report the synthesis and biological evaluation of the new compounds in which different structural modifications have been introduced in order to investigate their effects on RT inhibition.
