92633-19-7Relevant academic research and scientific papers
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII - A new scaffold for designing isoform-selective inhibitors
Carradori, Simone,De Monte, Celeste,D'Ascenzio, Melissa,Secci, Daniela,Celik, Gulsah,Ceruso, Mariangela,Vullo, Daniela,Scozzafava, Andrea,Supuran, Claudiu T.
supporting information, p. 6759 - 6763 (2014/01/06)
Salen and tetrahydrosalen derivatives possess metal-chelating properties and have been used as ligands in organic synthesis and as scaffolds for developing therapeutic agents. Fourteen such compounds were synthesized in order to explore their ability to inhibit the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). Human (h) isoforms hCA I, hCA II, hCA IX and hCA XII were included in the investigation. Several aliphatic and aromatic spacers were introduced between the two chelating groups from salen/tetrahydrosalen in order to explore a diverse chemical space for designing CA inhibitors, which incorporate both phenol and polyamine fragments in their molecule. Some of these compounds showed CA inhibitory activity in the low micromolar-nanomolar range and a pronounced selectivity for inhibiting an isoform over-expressed in hypoxic tumors, hCA XII, over hCA I, II and IX.
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
Tripathi,Saxena, Nisha,Tiwari,Verma,Chaturvedi, Vinita,Manju,Srivastva,Gaikwad,Sinha
, p. 8186 - 8196 (2007/10/03)
A total of 42 benzyl- and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of Mycobacterium tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/mL. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12 μg/mL.
