92656-06-9

Upstream product

• 108-24-7 acetic anhydride 
• 262849-41-2 Acetic acid (2R,3R)-3-hydroxy-3-(4-methoxy-phenyl)-2-methyl-propyl ester 
• 126356-04-5 (E)-methyl 2-methyl-3-(p-methoxyphenyl)prop-2-enoate 
• 91970-30-8 (E)-3-(4-Methoxyphenyl)-2-methylprop-2-en-1-ol 
• 17226-85-6 α,β-syn-methyl 3-hydroxy-2-methyl-3-(p-methoxyphenyl)propionate 
• 17226-85-6 α,β-anti-methyl 3-hydroxy-2-methyl-3-(p-methoxyphenyl)propionate 

Downstream Products

• 262849-39-8 (2S)-1-acetoxy-2-methyl-3-p-methoxyphenylpropane 
• 185681-33-8 (2S)-2-methyl-3-(p-methoxyphenyl)-1-phenylsulfonylpropane 
• 79253-39-7 (S)-(-)-3-(4-methoxyphenyl)-2-methylpropan-1-ol 
• 185681-32-7 (S)-1-bromo-2-methyl-3-(p-methoxyphenyl)propanol 

Relevant academic research and scientific papers

Enantioselective synthesis of (2R,4'R,8'R)-α-tocopherol (Vitamin E) based on enzymatic function

Syntheses of (S)-chroman-2-carboxaldehyde congener 1 and (S)-chiral isoprene unit 3 were achieved based on the enzymatic acetylation of (±)- chroman-2-methanol 6 and (±)-(2,3)-anti-2-methyl-3-(p-methoxyphenyl)-1,3- propane diol 12, respectively. Synthesis of the side-chain part corresponding to (3R,7R)-3,7,11-trimethyldodecan-1-ol 27 was achieved by the coupling reaction of (S)-3 and (R)-3,7-dimethyloctyl iodide 4. The Wittig reaction of (3R,7R)-phosphonium salt 2 derived from (3R,7R)-27 and (S)-1 gave the olefin 28 which was subjected to catalytic hydrogenation to afford (2R,4'R,8'R)-α- tocopherol.