926890-49-5Relevant academic research and scientific papers
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines
Ghosh, Animesh,Mukherjee, Koushik,Jiang, Xinpeng,Zhou, Ying,McCarroll, Joshua,Qu, James,Swain, Pamela M.,Baigude, Huricha,Rana, Tariq M.
experimental part, p. 1581 - 1587 (2011/11/07)
RNA interference (RNAi) is a gene-silencing phenomenon whereby double-stranded RNA (dsRNA) triggers the sequence-specific degradation of homologous mRNA. RNAi has been quickly and widely applied to discover gene functions and holds great potential to prov
METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS
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Page/Page column 62; 6/17, (2008/06/13)
The present invention provides methods of carrying out the safe and reliable preparation of lipids comprising quaternary amines. Such lipids are especially suited for introducing therapeutic agents into cells or organisms. In particular, the lipids of the invention are suitable for the efficient transfer of gene therapy agents into mammalian cells or organisms in a cell type specific or tissue specific manner.
