92712-79-3

Upstream product

• 24610-50-2 5-(4-methoxybenzyl)-2-thiouracil 
• 74-88-4 methyl iodide 

Downstream Products

• 92712-80-6 2-<4-(5-bromo-3-methylpyridin-2-yl)butylamino>-5-(4-hydroxybenzyl)-pyrimidin-4-one 
• 109946-66-9 2-<4-(5-bromo-3-methylpyridin-2-yl)butylamino>-5-(4-hydroxy-3,5-di-iodobenzyl)-pyrimidin-4-one 
• 129528-46-7 2-[2-(5-Dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethylamino]-5-(4-hydroxy-benzyl)-1H-pyrimidin-4-one 

Relevant academic research and scientific papers

Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK and F 93479) and related compounds

A series of 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-4-pyrimidones is described containing a variety of substituents in the 5-position of the pyrimidone (isocytosine) ring. Good H2-receptor histamine antagonist activity is retained over a range of basic and neutral, polar and non-polar substituents and the majority of compounds are selective for the H2-receptor. Modifications have also been made to the furan ring and N,N-dimethylaminomethyl substituent and structure-activity observations are discussed. Compound (16f) 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(6-methyl-3- pyridylmethyl)-4-pyrimidone (SK and F 93479, lupitidine), a compound which shows an extended duration of anti-secretory activity in animal models, was selected for clinical investigation.

2-(3,5-SUBSTITUTED-2-PYRIDYLALKYLAMINO)-5-BENZYL-4-PYRIMIDONES

3,5-Disubstituted-2-pyridylalkylamino-5-optionally substituted benzyl-4-pyrimidones having histamine H 1-antagonist activity are disclosed.