92721-60-3

Basic information

• Product Name: 1,2,5,7a-tetrahydro-7-(hydroxyMethyl)-3H-Pyrrolizin-3-one
• Synonyms: 1,2,5,7a-tetrahydro-7-(hydroxyMethyl)-3H-Pyrrolizin-3-one
• CAS NO: 92721-60-3
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.17844
• Mol File: 92721-60-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,5,7a-tetrahydro-7-(hydroxyMethyl)-3H-Pyrrolizin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5,7a-tetrahydro-7-(hydroxyMethyl)-3H-Pyrrolizin-3-one(92721-60-3)
• EPA Substance Registry System: 1,2,5,7a-tetrahydro-7-(hydroxyMethyl)-3H-Pyrrolizin-3-one(92721-60-3)

Safety Data

• Hazardous Substances Data: 92721-60-3(Hazardous Substances Data)

Upstream product

• 103979-79-9 1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one 
• 116071-86-4 5-ethoxy-1-(3-ethoxycarbonylpropyl)pyrrolidin-2-one 
• 146336-62-1 1-(2,2-Bis-phenylsulfanyl-ethyl)-5-trimethylsilanylethynyl-pyrrolidin-2-one 
• 146336-63-2 1-(2-Benzenesulfonyl-2-chloro-ethyl)-5-trimethylsilanylethynyl-pyrrolidin-2-one 
• 146336-56-3 7-(Tributylstannanyl-trimethylsilanyl-methyl)-1,2,5,7a-tetrahydro-pyrrolizin-3-one 
• 146336-61-0 1-(2-Chloro-2-phenylsulfanyl-ethyl)-5-trimethylsilanylethynyl-pyrrolidin-2-one 
• 146336-59-6 5-Hydroxy-1-(2-phenylsulfanyl-ethyl)-5-trimethylsilanylethynyl-pyrrolidin-2-one 
• 146336-60-9 1-(2-Phenylsulfanyl-ethyl)-5-trimethylsilanylethynyl-pyrrolidin-2-one 
• 146336-69-8 6-Phenylselanyl-7-[1-trimethylsilanyl-meth-(Z)-ylidene]-hexahydro-pyrrolizin-3-one 
• 146336-57-4 1-(2-Phenylsulfanyl-ethyl)-pyrrolidine-2,5-dione 
• 86436-55-7 5-ethoxy-1-<2-(phenylthio)ethyl>pyrrolidin-2-one 
• 92762-55-5 1-(2,3-butadienyl)-5-(phenylseleno)-2-pyrrolidinone 
• 92721-47-6 1-(2,3-butadienyl)-2,5-pyrrolidinedione 
• 103979-80-2 1-(3-diazo-3-ethoxycarbonylpropyl)-5-phenylthiopyrrolidin-2-one 

Downstream Products

• 23185-51-5 (+/-)-supinidine 

Relevant articles and documents

Phosphine-Catalyzed (4+1) Annulation: Rearrangement of Allenylic Carbamates to 3-Pyrrolines through Phosphonium Diene Intermediates

We have developed a phosphine-catalyzed (4+1) annulative rearrangement for the preparation of 3-pyrrolines from allenylic carbamates via phosphonium diene intermediates. We employed this methodology to synthesize an array of 1,3-disubstituted- and 1,2,3-t

A radical approach to the synthesis of (±)-supinidine

Intramolecular addition of α-sulfonyl radicals to triple bonds followed by addition of tin radicals to the resulting allylsulfones gave pyrrolizidine skeletons. Subsequent manipulations led to a formal synthesis of (±)-supinidine.

Synthesis of pyrrolizidine alkaloids, (±)-trachelanthamidine, (±)-isoretronecanol, and (±)-supinidine, by means of an intramolecular carbenoid displacement (ICD) reaction

-