927211-52-7

Upstream product

• 116627-69-1 (4R,6S)-6-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one 
• 915201-15-9 ethyl (3R,5S)-3-tert-butyldiphenylsilyloxy-5,6-(isopropylidenedioxy)hexanoate 
• 110772-23-1 [(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 116697-27-9 ((2S,4R)-2-Benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane 
• 116697-28-0 (4R,6S)-6-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol 
• 91312-53-7 ethyl (3R,5S)-5,6-O-isopropylidene-3,5,6-trihydroxyhexanoate 

Downstream Products

• 927211-53-8 (4R,6S)-4-tert-butyldiphenylsilyloxy-6-(p-tosyloxymethyl)tetrahydropyran-2-one 
• 116627-67-9 (4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one 

Relevant academic research and scientific papers

Synthesis of the chiral side chain of statins - Lactone versus lactol pathway

4-O-Protected (4R,6S)-4-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-ones (3) derived from enantiomerically pure (3R,5S)-3-hydroxy-5,6-(isopropylidenedioxy) hexanoates (2) are frequently considered as pivotal intermediates for the synthesis of pharmacologic

SYNTHESES OF 4(R)-SILYLOXY-6(S)-IODOMETHYL-TETRAHYDROPYRAN-2-ONE AND ITS ENANTIOMER, BUILDING BLOCKS FOR HMG-COA REDUCTASE INHIBITORS

Optically pure 4(R),6(S)-iodolactone 1 was obtained from α-D-(+)-glucose in 17 steps with 17percent overall yield.Its enantiomer 4(S),6(R)-iodolactone 1' was obtained from acetonedicarboxylic acid in 9 steps in 37percent overall yield and with 70percent e