92722-88-8Relevant articles and documents
Conformational Studies by Dynamic NMR. 62.1 Stereomutations of Rotamers and of Conformational Enantiomers in 1,2-Diacylbenzenes
Casarini, Daniele,Lunazzi, Lodovico,Mazzanti, Andrea
, p. 7592 - 7596 (1997)
A number of 1,2-diacylbenzenes have been investigated by dynamic NMR spectroscopy. The 1,2-formyl derivative 1 was found to exist (at -162 °C) in the nearly coplanar ZE and EE conformations (70percent and 30percent, respectively) that interconvert with a free energy of activation of 4.9 kcal mol-1. On the contrary, the more hindered 1,2-diisobutanoylbenzene (4) adopts a twisted conformation (as indicated by the 13C spectrum at -157 °C) which, in principle, might correspond either to a meso or to a racemic stereolabile structure. Only the racemic conformer is, however, believed to be populated, and the interconversion barrier between the RR and SS conformational enantiomers has been determined (5.6 kcal mol-1). Although the 1,2-diacetyl- and 1,2-dipropanoylbenzenes did not exhibit dynamic NMR effects in solution, they were assigned a twisted (racemic) conformation on the basis of the corresponding solid state 13C CP-MAS spectra, in that they display a 1:1 doublet signal for each pair of enantiotopic carbons. All these conclusions agree with the predictions of molecular mechanics calculations.
