92734-32-2

Upstream product

• 10364-94-0 1-benzoylimidazole 
• 54400-75-8 allyl 2-acetamido-2-deoxy-α-D-glucopyranoside 
• 7512-17-6 N-Acetyl-D-glucosamine 

Downstream Products

• 92734-33-3 ally 2-acetamido-3,6-di-O-benzoyl-4-O-(p-bromophenylsulfonyl)-2-deoxy-α-D-glucopyranoside 
• 946495-21-2 alIyI 2-acetamido-3,6-di-O-benzoyl-2-deoxy-4-O-((1-imidazoIido)-thiocarbonyl)-α-D-glucopyranoside 
• 946495-20-1 aIlyI 2-acetamido-3,6-di-O-benzoyl-2-deoxy-4-O-methyI-α-D-gIucopyranoside 
• 89023-79-0 allyl 2-acetamido-3,4,6-tri-O-benzoyl-2-deoxy-α-D-galactopyranoside 
• 92734-35-5 allyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-galactopyranoside 
• 92734-34-4 allyl 2-acetamido-3-O-benzyl-2-deoxy-α-D-galactopyranoside 
• 92841-85-5 allyl 2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 333969-14-5 allyl (2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-(1→3)-2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 155739-81-4 (2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-(1-3)-2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 92841-84-4 allyl 2-acetamido-2-deoxy-4,6-O-benzylidene-α-D-galactopyranoside 
• 141019-98-9 Allyl-2-acetamido-3,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosid 
• 141043-87-0 Allyl-2-acetamido-3,6-di-O-benzoyl-2-desoxy-4-O-(trifluormethylsulfonyl)-α-D-glucopyranosid 

Relevant academic research and scientific papers

Synthesis of Galα(1,3)Galβ(1,4)GlcNAcα-, Galβ(1,4)GlcNAcα- and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease

The protozoan parasite, Trypanosoma cruzi, the etiologic agent of Chagas disease (ChD), has a cell surface covered by immunogenic glycoconjugates. One of the immunodominant glycotopes, the trisaccharide Galα(1,3)Galβ(1,4)GlcNAcα, is expressed on glycosylp

Synthesis and protein binding properties of T-antigen containing GlycoPAMAM dendrimers

Allyl O-(β-D-galactopyranosyl)-(1-3)-2-acetamido-2-deoxy-α-D-galactopyranoside (8) was prepared in excellent yield from the corresponding galactosyl bromide (6, 7) and allyl 2-acetamido-4,6-benzylidine-2-deoxy-α-D-galactopyranoside (5) using Hg(CN)2 as a promoter. Compound 5 was obtained from N-acetylglucosamine 1 following sequential protecting group strategy and C-4 epimerization as a key step. Carboxylic acid functionalized T-antigen derivative 15, obtained by radical addition of 3-mercaptopionic acid to allyl disaccharide 10, was conjugated to PAMAM dendritic cores 13-16 by an efficient amide coupling strategy using TBTU. GlycoPAMAM dendrimers having T-antigen residues with 4, 8, 16 and 32 valencies (17-20) were obtained in 73 to 99% yields. Their protein binding properties were demonstrated using peanut lectin from Arachis hypogaea and a mouse monoclonal IgG antibody. The higher valency conjugates generated stronger binding interactions indicating a cluster effect. The inhibitory potential of these glycoPAMAM conjugates toward antibody-coating antigen interactions was enhanced up to 3800 times over that of the monomeric T-antigen residue (10). Copyright