927403-97-2Relevant academic research and scientific papers
Conversion of a pentane-1,3,5-triol derivative using lipases as chiral catalysts and possible function of the lid for the regulation of substrate selectivity and enantioselectivity
Koehler, Jens,Wuensch, Bernhard
scheme or table, p. 217 - 225 (2012/06/30)
The enantioselective desymmetrization of a prochiral 3-O-silyl protected pentane-1,3,5-triol derivative was achieved by lipase-catalysed hydrolysis. The lipase from B. cepacia led to 95.4% enantiomeric excess (ee)of the (R)-configured compound (R)-4 at a
Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ1 receptor ligands
K?hler, Jens,Bergander, Klaus,Fabian, J?rg,Schepmann, Dirk,Wünsch, Bernhard
, p. 8953 - 8957 (2013/01/15)
We synthesized and investigated the NMDA and σ1 receptor affinity of enantiomerically pure 2-(2-phenyl-1,3-dioxan-4-yl)ethanamines 17-26. The primary amines (R,R)-18-20 with an axially oriented phenyl moiety in position 2 interacted with high e
Lipase catalyzed enantioselective desymmetrization of a prochiral pentane-1,3,5-triol derivative
Koehler, Jens,Wuensch, Bernhard
, p. 3091 - 3099 (2007/10/03)
The enantioselective desymmetrization of the prochiral 3-O-silyl protected pentanetriol derivative 3 was carefully investigated. At -10 °C, the bacterial lipase from Burkholderia cepacia immobilized on ceramic particles led to monoacetate (S)-4 in 52% yie
