927438-82-2

Upstream product

• 56777-24-3 benzyl (S)-Lactate 
• 410087-03-5 (4R,5S,2'R,3'R)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone 
• 410087-14-8 (2R,3R)-3-amino-2-methylhexanoic acid 
• 260395-13-9 (4R,5S,2'R,3'S)-3-(3'-hydroxy-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone 
• 927438-80-0 3-tert-butoxycarbonylamino-2-methyl-hexanoic acid 
• 927438-77-5 benzyl (2R,3R)-3-(Boc-amino)-2-methylhexanoyl-L-lactic acid 

Downstream Products

• 927438-81-1 3-{[2-(1-tert-butoxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-2-methyl-hexanoic acid 1-benzyloxycarbonyl-ethyl ester 
• 1418192-73-0 C₄₆H₆₅N₅O₁₀S 
• 1418192-49-0 O-methylulongamide B 
• 1418192-50-3 O-methylulongamide C 
• 1418192-71-8 C₄₂H₆₅N₅O₁₀S 
• 927438-79-7 3-{[2-(1-tert-butoxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-2-methyl-hexanoic acid 1-({1-[(1-tert-butoxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-ethyl ester 

Relevant academic research and scientific papers

Synthesis of o -me ulongamide b and o -me ulongamide c, natural modified cyclodepsipeptides

Synthesis of O-Me ulongamide B and O-Me ulongamide C, modified natural cyclodepsipeptides, was achieved by a convergent route. The respective dipeptides and tridepsipeptides were coupled, obtaining linear depsipentapeptides, which were then deprotected and cyclized. These compounds were tested against three different types of human carcinoma cells and showed only moderate activity.

Total synthesis of ulongamide A, a cyclic depsipeptide isolated from marine cyanobacteria Lyngbya sp.

A total synthesis of ulongamide A (1), a cytotoxic natural cyclic depsipeptide, was achieved by a convergent route involving coupling of the fragments 7 and 8 to the pentapeptide 24, and subsequent cyclization thereof after prior removal of the t-Boc protecting groups.