92755-31-2Relevant academic research and scientific papers
One-pot synthesis of 1, 2-disubstituted 4-, 5-, 6-, and 7-azaindoles from amino-o-halopyridines via n-arylation/sonogashira/cyclization reaction
Purifica??o, Sara I.,Pires, Marina J.D.,Rippel, Rafael,Santos, A. Sofia,Marques, M. Manuel B.
, p. 5118 - 5121 (2017)
A direct synthesis of several 1, 2-disubstituted 4-, 5-, 6-, and 7-azaindoles from available amino-o-halopyridines is described. This procedure involves a palladium-catalyzed N-arylation followed by a Sonogashira reaction and subsequent cyclization in a one-pot manner, exhibiting a wide scope and compatibility with electron-withdrawing and electron-donating groups. The strategy represents an advancement in azaindole chemistry with a straightforward approach toward 1, 2-disubstituted azaindoles, while avoiding complex N-arylations of hindered 2-substituted azaindoles and difficult purification steps of intermediates.
Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents
Dandela, Rambabu,Nath Singh, Shambhu,Pal, Manojit,Ramamohan, Hindupur,Siddaiah, Vidavalur,Venkateshwarlu, Rapolu
supporting information, (2019/11/28)
Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives has been achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodology involved initial C[sbnd]N bond forming
