92762-94-2Relevant academic research and scientific papers
2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues
Bissyris, Evangelos E.,Belekos, Dimitris,Magafa, Vassiliki,Tsoungas, Petros G.,Varvounis, George,Cordopatis, Paul
, p. 3159 - 3166 (2007/10/03)
2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid (4) (ATPC) is an unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics. ATPC was obtained from both 3a and 3b thienopyrimidines by hydrolysis and hydrogenolysis, respectively. The synthesis of eleven ATPC-amino acids and two ATPC-peptides is described. ATPC is incorporated as N-terminal moiety in solution or solid-phase peptide synthesis using Boc or Fmoc methodology and without protection of the ATPC amino group. Georg Thieme Verlag Stuttgart.
Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics
Leite, Ana Cristina L.,Vieira, Renata F.,De Faria, Antonio R.,Wanderley, Almir G.,Afiatpour, Parviz,Ximenes, Eulalia Camelo P. A.,Srivastava, Rajendra M.,De Oliveira, Claudia F.,Medeiros,Antunes, Edson,Brondani, Dalci J.
, p. 719 - 724 (2007/10/03)
A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the
