92763-47-8Relevant academic research and scientific papers
Design of chelate ring-opening platinum anticancer complexes: Reversible binding to guanine
Habtemariam, Abraha,Sadler, Peter J.
, p. 1785 - 1786 (2007/10/03)
Chelate ring-opening in bis(aminophosphine) complexes of platinum(II) can be controlled by the substituents on N and P under biologically relevant conditions of pH and Cl- concentration; selective and reversible binding to the DNA base guanine can be achieved as well as cytotoxicity towards cancer cell lines.
Platinum (II) complexes of unsymmetrical, potentially bidentate ligands
Anderson, Gordon K.,Kumar, Ravi
, p. 4064 - 4068 (2008/10/08)
The reactions of a series of unsymmetrical, potentially bidentate ligands Ph2P(CH2)nX (n = 2, X = OMe, NMe2, SMe; n = 3, X = NMe2) with [PtX2(cod)] (X = Cl, I) are described. The tendency of the ligand to bond to the metal in a bidentate fashion is dependent on the nature of the weak donor, and on the size of the chelate ring formed. Halide abstraction by Ag+ promotes coordination of the ether function to yield [PtCl(Ph2PCH2CH2OMe)2]+ and [Pt(Ph2PCH2CH2OMe)2]2+. Reactions of the former with a number of weak donor ligands have been studied by 31P{1H} NMR spectroscopy. Complex mixtures are obtained with Ph2PCH2CH2SMe, and the involvement of ion-paired species is suggested in this case.
