92764-06-2Relevant articles and documents
Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5- trioxoimidazolidine-1-acetic acids
Ishii,Kotani,Nagaki,Shibayama,Toyomaki,Okukado,Ienaga,Okamoto
, p. 1924 - 1927 (2007/10/03)
A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)IC50(AR) was > 1000 in some compounds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5- trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.
Synthesis of Substituted 2-Imidazolidinones and Annelated Hydantions via Aminoalkylation Transformations
Liao, Zeng-Kun,Kohn, Harold
, p. 4745 - 4752 (2007/10/02)
The synthetic utility of 4-hydroxy-2-imidazolidinone amidoalkylation reactions is limited by the propensity of the carbon-5 unsubstituted and carbon-5 monosubstituted adducts to undergo dehydration to yield 2-imidazolones.Two techniques are reported which