927700-73-0Relevant academic research and scientific papers
A new flow methodology for the expedient synthesis of drug-like 3-aminoindolizines
Lange, Paul P.,Bogdan, Andrew R.,James, Keith
supporting information, p. 2373 - 2379 (2012/10/30)
A flow-based synthesis of diversely functionalized indolizines and their aza-analogues is described. These drug-like heterocycles were generated via a tandem Sonogashira/cycloisomerization sequence, starting from widely available 2-bromopyridines and alkynes, employing a simple catalyst system together with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base. The use of flow technology allows a straightforward and rapid access to a variety of novel compounds, and enables linear scale-up from milligram- to gram-scales without a decrease in yield. Copyright
Highly regioselective palladium-Catalyzed oxidative coupling of indolizines and vinylarenes via C-H bond cleavage
Yang, Yuzhu,Cheng, Kal,Zhang, Yuhong
supporting information; experimental part, p. 5606 - 5609 (2010/03/02)
[Chemical Equation Presented] A highly regloselective oxidative coupling reaction between indolizines and vinylarenes has been accomplished In the presence of palladium catalysts to give only the branched α-product In high efficiency. The regioselectivity Is promoted significantly by bidentate nitrogen Uganda.
General and direct synthesis of 3-aminoindolizines and their analogues via Pd/Cu-catalyzed sequential cross-coupling/cycloisomerization reactions
Liu, Yuanhong,Song, Zhiquan,Yan, Bin
, p. 409 - 412 (2008/02/12)
An efficient and one-step synthesis of 3-aminoindolizines or benz[e]indolizines from the reactions of propargyl amines or amides with heteroaryl bromides was developed. This methodology is realized by a tandem reaction using Pd/Cu catalysts, which could c
