927962-41-2Relevant academic research and scientific papers
Palladium-Catalyzed Dearomatizing Difunctionalization of Indoles and Benzofurans
Ramella, Vincenzo,He, Zhiheng,Daniliuc, Constantin G.,Studer, Armido
, p. 2268 - 2273 (2016)
A palladium-catalyzed dearomatizing difunctionalization of N-Boc-indoles and benzofurans to give tricyclic indolines and 2,3-dihydrobenzofurans with a fully substituted carbon center is described. Product formation occurs under mild conditions at room temperature with commercially available aryl boronic acids and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as a mild oxidant in good yields. 2-Carboxyalkyl-substituted indoles and benzofurans react under Pd-catalysis with aryl boronic acids and TEMPO through dearomatizing arylation/cyclization to the corresponding indolines and dihydrobenzofurans containing a lactone moiety bearing a fully substituted carbon center.
Indole Compounds, Method of Preparing Them and Uses Thereof
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Page/Page column 9, (2008/12/06)
Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacol
