928017-68-9Relevant academic research and scientific papers
Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method
Kato, Terukazu,Ohara, Takafumi,Suzuki, Naoyuki,Muto, Susumu,Tokuyama, Ryukou,Mizutani, Miho,Fukasawa, Hiroshi,Matsumura, Ken-ichi,Itai, Akiko
, (2022/01/26)
Novel PPARδ agonists, 2-(1-piperidinyl)-1,3-benzothiazole derivatives were discovered by our proprietary docking-based virtual screening technique. Compound 1 as the initial hit was effectively modified to acquire PPARδ agonist activity, resulting in the discovery of compound 12 with high agonistic potency for PPARδ and selectivity over PPARα and PPARγ. Compound 12 also had good ADME profiles and showed in vivo efficacy as a lead.
DERIVATIVE HAVING PPAR AGONISTIC ACTIVITY
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Page/Page column 158, (2008/12/06)
A compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein Ring Q is optionally substituted monocyclic aryl, optionally substituted monocyclic heteroaryl, optionally substituted fused aryl or optionally substituted fused heteroaryl, Y1 is a bond or -NR6- or the like, Ring A is optionally substituted nonaromatic heterocyclediyl, a group of the formula: -Y2 Z1- is a group of the formula: or R7 are each independently hydrogen, optionally substituted lower alkyl or the like, R8 and R9 are each independently hydrogen or optionally substituted lower alkyl, n is an integer between 1 and 3, Z1 is a bond, -O-, -S- or -NR9-, Ring B is optionally substituted aromatic carbocyclediyl or optionally substituted aromatic heterocyclediyl, Y3 is a bond, optionally substituted lower alkylene optionally intervened by -O-, optionally substituted lower alkenylene or the like, and Z2 is COOR3 or the like.
