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Usage

Uses

Used in Pharmaceutical Industry:
(S)-methyl N-(aminocarbonyl)phenylalaninate is used as a building block for the synthesis of pharmaceuticals and biologically active compounds, due to its versatile chemical structure and potential for modification.
Used in Pain Management:
(S)-methyl N-(aminocarbonyl)phenylalaninate is used as a precursor in the production of opioid peptides, which are crucial for managing pain and other medical uses.
Used in Neuroscience Research:
(S)-methyl N-(aminocarbonyl)phenylalaninate is used as a precursor to molecules that modulate neurotransmitter activity in the brain, contributing to the understanding and treatment of neurological disorders.

Upstream product

• 590-28-3 potassium cyanate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 1032442-21-9 C₁₁H₁₂N₂O₂ 

Downstream Products

• 40857-14-5 (5S)-(phenylmethyl)-2,4-imidazolidinedione 
• 114840-94-7 4-benzyl-1,3-dihydro-imidazol-2-one 

Relevant academic research and scientific papers

Mechanochemical preparation of hydantoins from amino esters: Application to the synthesis of the antiepileptic drug phenytoin

The eco-friendly preparation of 5- and 5,5-disubstituted hydantoins from various amino ester hydrochlorides and potassium cyanate in a planetary ball-mill is described. The one-pot/two-step protocol consisted in the formation of ureido ester intermediates, followed by a base-catalyzed cyclization to hydantoins. This easy-handling mechanochemical methodology was applied to a large variety of α- and β-amino esters, in smooth conditions, leading to hydantoins in good yields and with no need of purification steps. As an example, the methodology was applied to the "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful organic solvent.

Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.

METHOD OF MAKING IMIDAZOLE-2-ONES AND 2-THIONES

A method of making 4-substituted imidazole-2-ones and thiones which comprises reacting a methylene urea or methylene thiourea wherein said methylene is substituted with the 4-subsituent and a cyano or alkycarboxylate group to provide said 4-substituted im