92806-48-9Relevant academic research and scientific papers
Reactions of 2-Diazo-1,2-Diphenylethanone and Diphenyldiazomethane with Ketohydrazones
Singh, Giria Shankar,Singh, Surendra Bahadur,Mehrotra, Kailash Nath
, p. 1667 - 1670 (1984)
The reactions of 2-diazo-1,2-diphenylethanone (1) with ketohydrazones (3a-c) in equimolecular ratio yield (diphenylacetyl)hydrazones (4a-c) of the corresponding benzophenones which on further treatment with 1 in equimolecular ratio leads to 1-diphenylacetylazo-1,1,3,3-tetraaryl-2-propanones (5a-c).The product 5a is also obtained in the reaction of 1 with benzophenone hydrazone (3a) in 2:1 molecular ratio.The bis(acetylacetonato)copper(II)-catalyzed reaction of 1 and also of diphenyldiazomethane (2) with ketohydrazones (3) affords ketazines (6).The mechanistic route for the formation of products is discussed.
Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents
Al-Kahraman, Yasser M.S.A.,Yasinzai, Masoom,Singh, Girija S.
experimental part, p. 1009 - 1013 (2012/10/08)
The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,- Demthoxybenzil monohydrazone and 4,4'-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
