92808-80-5

Upstream product

• 50-00-0 formaldehyd 
• 88159-06-2 tert-butyl(diphenyl)(2-propynyloxy)silane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 110-65-6 1,4-dihydroxybut-2-yne 

Downstream Products

• 92808-86-1 tert-butyl ((4-chlorobut-2-yn-1-yl)oxy)diphenylsilane 
• 328092-75-7 (Z)-2-iodo-1-(tert-butyldiphenylsiloxy)but-2-en-4-ol 
• 436147-06-7 4-iodo-1-(tert-butyldiphenylsiloxy)but-2-yne 
• 851531-09-4 N-allyl-N-(4-(tert-butyldiphenylsilyloxy)but-2-ynyl)-4-methylbenzenesulfonamide 
• 131380-48-8 (E)-4-(t-butyldiphenylsilyl)oxy-2-butenal 
• 1097628-35-7 C₃₆H₃₇N₃O₄Si 
• 1031401-18-9 3-(4-((tert-butyldiphenylsilyl)oxy)but-2-yn-1-yl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione 
• 1290544-03-4 (2R)-7-O-tert-butyldiphenylsilyl-1,2-O-isopropylidenehept-5-yne-1,2,3,7-tetrol 
• 1290544-02-3 1-O-tert-butyldiphenylsilyl-2-deoxy-2-C-ethenylidene-4,5-O-isopropylidene-D-erythro-pentitol 
• 1434003-12-9 3-(t-butyldiphenylsilyl)oxymethyl-N-methoxy-N-methylpena-3,4-dienamide 
• 1434003-13-0 5-((t-butyldiphenylsilyl)oxymethyl)hepta-5,6-dien-1-yn-3-one 
• 1434003-14-1 5-((t-butyldiphenylsilyl)oxymethyl)hepta-5,6-dien-1-yn-3-ol 
• 1434003-15-2 5-methoxy-3-(( t-butyldiphenylsilyl)oxymethyl)hepta-1,2-dien-6-yne 
• 1434003-16-3 methyl 4-methoxy-6-((t-butyldiphenylsilyloxy)methyl)octa-6,7-dien-2-ynoate 

Relevant academic research and scientific papers

Neutral Organic Super Electron Donors Made Catalytic

Neutral organic super electron donors (SEDs) display impressive reducing power but, until now, it has not been possible to use them catalytically in radical chain reactions. This is because, following electron transfer, these donors form persistent radical cations that trap substrate-derived radicals. This paper unlocks a conceptually new approach to super electron donors that overcomes this issue, leading to the first catalytic neutral organic super electron donor.

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter

A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of conc

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): (Formula I), wherein Z1 is NR1A, CHR1A or CR1BR1B; one of Z2 and Z3 is CH or CR1A', the other is N, CH or CR1A'; n is 0, 1 or 2; q is 0, 1 or 2; R1A, R1A', R1B, R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.

Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist

Our research found that the 2-hydroxyacetophenone derivative is an outstanding linker between the 1,1-bistrifluoromethylcarbinol moiety and the imidazolidine-2,4-dione moiety to enhance the potency and β-selectivity of liver X receptor (LXR) agonist in ou

SUBSTITUTED CARBINOL COMPOUND

There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caus

An atom-economic and selective ruthenium-catalyzed redox isomerization of propargylic alcohols. An efficient strategy for the synthesis of leukotrienes

Catalytic ruthenium complexes in conjunction with an indium cocatalyst and Broensted acid isomerize primary and secondary propargylic alcohols in good yields to provide trans enals and enones exclusively. Readily available indenylbis(triphenylphosphine)ruthenium chloride, in the presence of indium triflate and camphorsulfonic acid, gives the best turnover numbers and reactivity with the broadest range of substrates. Deuterium labeling experiments suggest that the process occurs through propargylic hydride migration followed by protic cleavage of the resultant vinylruthenium intermediate. Application of this method to the synthesis of leukotriene B4 demonstrates its utility and extraordinary selectivity.

A divergent synthesis of triyne natural products and glycosylated analogues using a carbenoid rearrangement

Using a carbenoid rearrangement to introduce the conjugated acetylenic framework, a series of triynols has been synthesized in five steps from 1,4-butynediol. Several of the triyne alcohols are known natural products and others are glycosylated analogues.

Thioureas as ligands in the Pd-catalyzed intramolecular Pauson-Khand reaction

(Chemical Equation Presented) The thiourea-Pd complex was established as a novel type of catalyst in the PKR of allylpropargylamine, and the demonstrated chemistry may prove to be valuable for developing thiuorea as a ligand for the Pd-catalyzed Pauson-Kh

4-(Trialkylsilyl)oxybut-2-ynals as dienophiles in the Diels-Alder synthesis of α-(hydroxymethyl)benzaldehydes

The α-(hydroxymethyl)benzaldehyde derivative 2 has been synthesized by heating ynal 3 with diene 5, which produced the α-(silyloxymethyl)benzaldehyde 6 by a Diels-Alder/retro-Diels-Alder process, followed by methylation, thioacetalization, and removal of the silyl protecting group. Decarbonylation of α-(silyloxymethyl)benzaldehydes 6 and 10 takes place readily in the presence of zinc(II) chloride or para-toluenesulfonic acid.

gem-diacetates as carbonyl surrogates for asymmetric synthesis. Total syntheses of sphingofungins E and F

The equivalent of an asymmetric addition to a carbonyl group with a stabilized anion is accomplished by discriminating between the enantiotopic C-O single bonds of a gem-diacetate. In this way, enantioselective total syntheses of two antifugal agents, sph