928112-98-5

Upstream product

• 74181-34-3 2,2,-dimethyl-1,3-dioxan-5-one 
• 126178-08-3 N-(2,2-Dimethyl-1,3-dioxan-5-ylidene)-N-[(2'R)-2-(methoxymethyl)tetrahydro-1'H-1'-pyrrolyl]amine 

Downstream Products

• 928112-99-6 acetic acid 4-acetoxy-1-{5-[1-(tert-butyl-diphenyl-silanyloxy)-allyl]-2,6,6-trimethyl-cyclohex-1-enyl}-5-(2,2-dimethyl-5-methylene-[1,3]dioxan-4-yl)-pent-2-ynyl ester 
• 928113-03-5 acetic acid 4-acetoxy-6-hydroxy-1-[5-(1-hydroxy-allyl)-2,6,6-trimethyl-cyclohex-1-enyl]-7-hydroxymethyl-oct-7-en-2-ynyl ester 
• 928113-00-2 acetic acid 4-acetoxy-5-(2,2-dimethyl-5-methylene-[1,3]dioxan-4-yl)-1-[5-(1-hydroxy-allyl)-2,6,6-trimethyl-cyclohex-1-enyl]-pent-2-ynyl ester 
• 928113-04-6 acetic acid 3-hydroxy-1-{3-[5-(1-hydroxy-allyl)-2,6,6-trimethyl-cyclohex-2-enylidene]-prop-1-ynyl}-4-hydroxymethyl-pent-4-enyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of advanced intermediates en route to Taxuspine U and X: a study of macrocyclization via ring closing metathesis to highly constrained twelve-membered rings

The stereoselective synthesis of an advanced intermediate of Taxuspine U and X has been accomplished using a ring closing metathesis strategy. The feasibility of ring closing metathesis in synthesizing highly constrained and functionalized macrocycles has been demonstrated provided the appropriate substrate structure and substitution pattern are chosen.