928118-00-7

Basic information

• Product Name: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 6-aMino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate
• CAS NO: 928118-00-7
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.296
• Mol File: 928118-00-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(928118-00-7)
• EPA Substance Registry System: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(928118-00-7)

Safety Data

• Hazardous Substances Data: 928118-00-7(Hazardous Substances Data)

Usage

General Description

6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4- CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound that is a derivative of benzo[1,4]oxazine-4-carboxylic acid. It has a tert-butyl ester group attached to the carboxylic acid moiety and an amino group attached to the benzo[1,4]oxazine ring. 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER has potential applications in organic synthesis and pharmaceutical research due to its unique structure and potential biological activity. It may be used as a building block in the synthesis of other organic compounds or as a precursor in the development of new pharmaceutical drugs. Its chemical properties and potential applications make it a subject of interest in scientific research and development.

Upstream product

• 28226-22-4 6-nitro-1,4-benzoxazine 
• 81721-87-1 6-nitro-4H-benzo[1,4]oxazin-3-one 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 928118-23-4 tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate 

Downstream Products

• 1202759-97-4 C₂₃H₂₃ClFN₅O₃ 

Relevant articles and documents

Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

In an effort to design inhibitors of human glutaminyl cyclase (QC), we have synthesized a library of N-aryl N-(5-methyl-1H-imidazol-1-yl)propyl thioureas and investigated the contribution of the aryl region of these compounds to their structure-activity relationships as cyclase inhibitors. Our design was guided by the proposed binding mode of the preferred substrate for the cyclase. In this series, compound 52 was identified as the most potent QC inhibitor with an IC50 value of 58 nM, which was two-fold more potent than the previously reported lead 2. Compound 52 is a most promising candidate for future evaluation to monitor its ability to reduce the formation of pGlu-Aβ and Aβ plaques in cells and transgenic animals.