928154-75-0

Upstream product

• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 768-60-5 4-methoxyphenylacetylen 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1379536-64-7 N-allyl-N-(8-fluoro-1-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-61-4 N-allyl-N-(1-(4-methoxyphenyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-58-9 N-allyl-N-(1-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-69-2 N-(but-2-en-1-yl)-N-(1-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-73-8 (E)-N-(but-2-en-1-yl)-N-(1-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1433141-19-5 N-allyl-2-(4-methoxyphenyl)-2-oxo-N-tosylacetamide 

Relevant academic research and scientific papers

Synthesis of 3-aza-bicyclo[3.1.0]hexan-2-one derivatives via gold-catalyzed oxidative cyclopropanation of N -allylynamides

N-Allylynamides with various functional groups and different substitution patterns can be converted into 3-aza-bicyclo[3.1.0]hexan-2-one derivatives in moderate to high yield using IMesAuCl/AgBF4 as the catalyst and pyridine N-oxide as the oxidant. A noncarbene mediated approach is proposed as the mechanism.

Silylcupration and copper-catalyzed carbomagnesiation of ynamides: Application to aza-Claisen rearrangement

Treatment of ynamides with silylcopper reagents resulted in silylcupration to afford (E)-ss-silylenamides, after protonolysis, in good yields with high regio- and stereoselectivity. Reaction of ynamides having an allyl group on the nitrogen with Grignard reagents in the presence of a copper catalyst resulted in carbomagnesiation across the alkynyl unit and subsequent heating provided 4-pentenenitriles via aza-Claisen rearrangement.