928168-72-3Relevant academic research and scientific papers
Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis
Gundersen, Lise-Lotte,Charnock, Colin,Negussie, Ayele Hailu,Rise, Frode,Teklu, Solomon
, p. 26 - 35 (2007/10/03)
1-Substituted indolizines with activity against Mycobacterium tuberculosis have been synthesized. The most active compounds carry an hydroxyphenylmethyl- or hydroxyalkyl substituent in the indolizine 1-position. The alkyl chain should be moderately long (C-5 or C-6). Aryl groups in the 2- and 3-position of the indolizine are also required. Removal of the 3-substituent resulted in significant loss of activity. A nitrile substituent in the 7-position is beneficial for both chemical stability and bioactivity. The compounds studied display a narrow antibacterial spectrum and appear to be quite selective antimycobacterial compounds. Moderate activity against certain pathogenic protozoa was also observed.
