92822-01-0

Basic information

• Product Name: 4-(4-METHYL-BENZYL)-PIPERIDINE
• Synonyms: 4-(4-METHYL-BENZYL)-PIPERIDINE;4-[(4-methylphenyl)methyl]Piperidine
• CAS NO: 92822-01-0
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.3
• Mol File: 92822-01-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.525
• PKA: 10.60±0.10(Predicted)
• CAS DataBase Reference: 4-(4-METHYL-BENZYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYL-BENZYL)-PIPERIDINE(92822-01-0)
• EPA Substance Registry System: 4-(4-METHYL-BENZYL)-PIPERIDINE(92822-01-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 92822-01-0(Hazardous Substances Data)

Usage

General Description

4-(4-Methyl-benzyl)-piperidine is a chemical compound that belongs to the piperidine class of organic compounds. It is a cyclic amine with a piperidine backbone and a 4-methyl-benzyl substituent. 4-(4-METHYL-BENZYL)-PIPERIDINE is used in the synthesis of various pharmaceuticals and organic compounds. It is also used as a building block in organic synthesis for the preparation of complex molecules. Its structure and properties make it suitable for use as an intermediate in the production of a wide range of chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals.

InChI:InChI=1/C13H19N/c1-11-2-4-12(5-3-11)10-13-6-8-14-9-7-13/h2-5,13-14H,6-10H2,1H3

Upstream product

• 242487-87-2 1-benzyl-4-(4-methylbenzylidene)piperidine 
• 33974-28-6 α-(4-methylphenyl)-4-pyridinemethanol 
• 104-82-5 4-Methylbenzyl chloride 
• 3762-25-2 diethyl 4-methylbenzylphosphonate 
• 106-38-7 para-bromotoluene 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 193356-65-9 4-(-4-Methylbenzyl)-1-(2-(4-methylaminophenoxy)ethyl)piperidine 
• 193356-84-2 4-(4-Methylbenzyl)-1-(2-(2-hydroxynaphth-6-oxy)ethyl)piperidine 
• 338466-88-9 2-{3-[4-(4-methyl-benzyl)-piperidin-1-yl]-propyl}-1H-benzimidazole 

Relevant articles and documents

20-HETE FORMATION INHIBITORS

This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.

2-[(4-BENZYL)-1-PIPERIDINYL)METHYL]BENZIMIDAZOLE-5-OL DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS

2-[(4-Benzyl)-1-piperidinyl)-methyl]benzimidazole-5-ol derivatives are NMDA NR2B receptor antagonists useful in the treatment of pain and other NMDA mediated diseases.

Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives

Compounds of the formula: STR1 wherein R1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R2 is hydroxyl or methoxy in the 4-position and R3 is hydrogen, R1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl, R2 is hydrogen, halogen, alkyl, hydroxyl, or alkoxy, R3 is hydrogen or alkyl, R4 is alkyl (in which case the compounds are (±)-erythro) or when R3 represents hydrogen, R4 may also be hydrogen, and R5 is hydrogen, halogen, alkyl, alkoxy, or three methoxy groups in the 3-, 4- and 5-positions and pharmaceutically acceptable acid addition salts thereof, with the exclusion of compounds wherein: (a) one of R1 and R2 is in the 4-position and is hydroxyl, alkoxy or benzyloxy, the other is in the 3-position and is hydrogen, hydroxyl, alkoxy or benzyloxy, and R3 and R5 are hydrogen and wherein: (b) R1 is in the 4-position and is halogen, R4 is methyl and R2, R3 and R5 are hydrogen, are useful as medicaments.