928309-80-2Relevant academic research and scientific papers
Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR
Takayama, Tetsuo,Umemiya, Hiroki,Amada, Hideaki,Yabuuchi, Tetsuya,Koami, Takeshi,Shiozawa, Fumiyasu,Oka, Yusuke,Takaoka, Akiko,Yamaguchi, Akie,Endo, Mayumi,Sato, Masakazu
experimental part, p. 112 - 116 (2010/04/02)
We have identified a novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good enzyme inhibitory activity (IC50s 50s 1 nM).
