928336-97-4Relevant academic research and scientific papers
Synthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi
Fan, Judi,Fan, Lingling,Li, Yi,Li, Yong,Liu, Xinyun,Luo, Zhongfu,Tang, Lei,Xue, Wei
, (2020/05/18)
A series of 3,6-disubstituted imidazo[1,2-b]pyridazine derivatives have been synthesized and characterized with spectroscopic analyses. The antifungal activities of these compounds against nine phytopathogenic fungi were evaluated by the mycelium growth rate method. The in vitro antifungal bioassays indicated that most of compounds displayed excellent and broad-spectrum antifungal activities. Especially, compounds 4a, 4c, 4d, 4l and 4r exhibited 1.9–25.5 fold more potent than the commercially available fungicide hymexazol against Corn Curvalaria Leaf Spot (CL), Alternaria alternate (AA), Pyricularia oryzae (PO) and Alternaria brassicae (AB) strains. Structure-activity relationship analysis showed that the enhanced antifungal activity is significantly affected by the substituents on the benzene ring and pyridazine ring.
FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS
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Paragraph 00505; 00506-00507, (2020/08/28)
Provided is a composition comprising a polyglycolized glyceride and a compound having the following structure (I): (I) or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of the compound of structure (I), or a pharmaceutically acceptable salt thereof. Methods of making the same, and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated diseases, disorders or conditions are also disclosed.
Application of 3,6-disubstituted imidazo[1, 2-b] pyridazine derivatives in preparation of fungicides
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Paragraph 0030; 0037-0038; 0075-0077; 0078-0082, (2020/06/20)
The invention belongs to the technical field of farm chemicals, and specifically relates to application of 3,6-disubstituted imidazo[1, 2-b] pyridazine derivatives in preparation of fungicides. The 3,6-disubstituted imidazo[1, 2-b] pyridazine derivatives are prepared and applied in farm chemical preparation. The inhibition activity of the derivatives on nine common plant pathogenic fungi is testedby adopting a hypha growth rate inhibition method; some of the derivatives show excellent fungistat activity, and are expected to be used for preventing and treating plant diseases caused by pathogenic fungi such as wheat scab, rice blast, cotton blight, tobacco brown spot, cabbage black spot, pumpkin blight, apple ring spot, Curvularia lunata(Walk) Boed and potato dry rot.
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
Bendjeddou, Lyamin Z.,Loa?c, Nadège,Villiers, Beno?t,Prina, Eric,Sp?th, Gerald F.,Galons, Hervé,Meijer, Laurent,Oumata, Nassima
, p. 696 - 709 (2016/10/13)
3,6-Disubstituted imidazo[1,2-b]pyridazine derivatives were synthesized to identify new inhibitors of various eukaryotic kinases, including mammalian and protozoan kinases. Among the imidazo[1,2-b]pyridazines tested as kinase inhibitors, several derivatives were selective for DYRKs and CLKs, with IC50?50?=?82?nM), CLK4 (IC50?=?44?nM), DYRK1A (IC50?=?50?nM), and PfCLK1 (IC50?=?32?nM). The compounds were also tested against Leishmania amazonensis. Several compounds showed anti-leishmanial activity at rather high (10?μM) concentration, but were not toxic at 1?μM or 10?μM, as judged by viability assays carried out using a neuroblastoma cell line.
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
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Page/Page column 145; 146; 147, (2016/09/13)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
HETEROCYCLIC PROTEIN KINASE INHIBITORS
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Paragraph 00360, (2013/03/26)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
