92845-58-4

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4800, 1984 DOI: 10.1021/jo00199a010

Upstream product

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Relevant academic research and scientific papers

ALKYNYL ALCOHOLS AS KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

Utility of p-Nitrophenyl 3-Bromo-2,2-diethoxypropionate (NPBDP) in Heterocyclic Synthesis

p-Nitrophenyl 3-bromo-2,2-diethoxypropionate (NPBDP, 3) reacts with a variety of nucleophiles at the activated ester to afford the corresponding 3-bromo-2,2-diethoxypropionylated derivatives.With bifunctional nucleophiles, propionylation can be followed b