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Upstream product

• 71565-77-0 (4-methoxyphenyl)sulfamoyl chloride 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 637031-08-4 2-oxopropane-1-sulfonyl chloride 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

Straightforward Route to γ-Sultams via Novel Tandem S N/Michael Addition

A novel tandem approach to trisubstituted γ-sultams has been developed involving N -alkylation of methanesulfonanilides with EWG-substituted allyl bromides followed by intramolecular Michael addition. A series of various isothiazolidine 1,1-dioxides have been prepared under mild transition-metal-free conditions in high yields and trans -diastereoselectivity (confirmed by X-ray crystallography). The dependence of reactivity on electronic properties of substrates has been investigated.

HETEROCYCLIC DIHYDROPYRIMIDINE COMPOUNDS

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra rapidly activating d