928627-62-7

Usage

Molecular structure

2(3H)-Benzothiazolone core with azide and hydroxyethyl groups attached.

Functional groups

Benzothiazolone ring, azide group, hydroxyethyl group, and phenylmethoxy group.

Stereochemistry

(1R) configuration at the 2-azido-1-hydroxyethyl group.

Fused rings

Benzene ring fused to a thiazole ring.

Nitrogen content

Nitrogen atoms present in the benzothiazolone and azide groups.

Potential applications

Organic synthesis, drug discovery, and bioconjugation strategies.

Click chemistry

Azide group can participate in click chemistry reactions for the formation of new bonds.

Bioconjugation

Azide group can be used for the attachment of biomolecules or other functional groups.

Upstream product

• 662111-36-6 4-(benzyloxy)-7-[(1R)-2-bromo-1-hydroxyethyl]-1,3-benzothiazol-2(3H)-one 
• 662111-34-4 7-acetyl-4-(benzyloxy)-1,3-benzothiazol-2(3H)-one 
• 662111-33-3 7-acetyl-4-hydroxy-1,3-benzothiazol-2(3H)-one 
• 662111-32-2 7-acetyl-4-methoxy-1,3-benzothiazol-2(3H)-one 
• 80567-66-4 4-methoxy-1,3-benzothiazol-2(3H)-one 
• 662111-35-5 4-(benzyloxy)-7-(bromoacetyl)-1,3-benzothiazol-2(3H)-one 

Downstream Products

• 948894-43-7 4-(benzyloxy)-7-{(1R)-1-hydroxy-2-[({1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one 

Relevant academic research and scientific papers

Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists

The design and synthesis of a new series of high efficacy β2-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2-adrenoceptor crystal structure, other biophysical data and modeling studies.

7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS

The present invention provides compounds of formula (I) wherein the variables are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS

The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS

The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.