928788-39-0Relevant articles and documents
Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors
Huang, Hui,Hutta, Daniel A.,Rinker, James M.,Hu, Aping,Parsons, William H.,Schubert, Carsten,Desjarlais, Renee L.,Crysler, Carl S.,Chaikin, Margery A.,Donatelli, Robert R.,Chen, Yanmin,Cheng, Deping,Zhou, Zhao,Yurkow, Edward,Manthey, Carl L.,Player, Mark R.
experimental part, p. 1081 - 1099 (2010/01/07)
A series of pyrido[2,3-d]pyrimidin-5-ones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). FMS inhibitors may be useful in treating rheumatoid arthritis and other chronic infla