92891-49-1

Basic information

• Product Name: 2C₈H₁₀⁽¹²⁵⁾IN₃*H₂O₄S
• CAS NO: 92891-49-1
• Molecular Weight: 644.454
• Mol File: 92891-49-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2C₈H₁₀⁽¹²⁵⁾IN₃*H₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: 2C₈H₁₀⁽¹²⁵⁾IN₃*H₂O₄S(92891-49-1)
• EPA Substance Registry System: 2C₈H₁₀⁽¹²⁵⁾IN₃*H₂O₄S(92891-49-1)

Safety Data

• Hazardous Substances Data: 92891-49-1(Hazardous Substances Data)

Upstream product

• 87862-25-7 meta-Iodobenzylguanidinium sulfate 

Relevant articles and documents

Adrenal medulla imaging agents: A structure-distribution relationship study of radiolabeled aralkylguanidines

Fourteen 125I-labeled aralkylguanidines were synthesized and evaluated as potential imaging agents for the adrenal medullae and tumors of adrenomedullary origin. These guanidines are radiotracer analogues of guanethidine, an antihypertensive agent thought to mediate neuron blockade by uptake into adrenergic nerves. Dog adrenal medullae were used as a model to test radiotracer affinity for catecholamine storage tissue. Tissue distribution studies revealed that a number of radioiodinated guanidines showed pronounced localization in the adrenal medullae following intravenous injection, in certain cases exceeding that of either (-)-[3H]norepinephrine or [14C]guanethidine. (m-[125I]Iodobenzyl)guanidine (m-IBG) gave the best combination of high concentration and selectivity. The low adrenomedullary affinity observed with [14C]guanidine and m-[125I]iodobenzylamine demonstrates the --- -------------- uniqueness of the aralkylguanidine structure. Preliminary evidence suggests that m-IBG is a storage analogue of norepinephrine. A second 125I-aralkylguanidine is now being used clincally in imaging and radiotherapy of catecholamine tumors, such as pheochromocytoma.