92892-06-3

Basic information

• Product Name: Phenol, 2,3,6-trimethyl-4-nitro-
• CAS NO: 92892-06-3
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Mol File: 92892-06-3.mol

Chemical Properties

• CAS DataBase Reference: Phenol, 2,3,6-trimethyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2,3,6-trimethyl-4-nitro-(92892-06-3)
• EPA Substance Registry System: Phenol, 2,3,6-trimethyl-4-nitro-(92892-06-3)

Safety Data

• Hazardous Substances Data: 92892-06-3(Hazardous Substances Data)

Upstream product

• 2416-94-6 2,3,6-trimethylphenol 

Downstream Products

• 142279-85-4 2-methoxy-1,3,4-trimethyl-5-nitrobenzene 
• 373642-16-1 2-(4-benzyloxy-3-isopropylphenoxy)-1,3,4-trimethyl-5-nitrobenzene 
• 373641-42-0 ethyl N-[4-(4-hydroxy-3-isopropylphenoxy)-2,3,5-trimethylphenyl]malonamate 
• 909572-73-2 2,3,6-trimethyl-4-nitrophenyl acetate 

Relevant articles and documents

Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia

Thyromimetics that specifically target TRβ have been shown to reduce plasma cholesterol levels and avoid atherosclerosis through the promotion of reverse cholesterol transport in an animal model. We designed novel thyromimetics with high receptor (TRβ) and organ (liver) selectivity based on the structure of eprotirome (3) and molecular modeling. We found that indane derivatives are potent and dual-selective thyromimetics expected to avoid hypothyroidism in some tissues as well as heart toxicity. KTA-439 (29), a representative indane derivative, showed the same high human TRβ selectivity in a binding assay as 3 and higher liver selectivity than 3 in a cholesterol-fed rat model.

TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF

The present invention provide a tetrahydroisoquinoline compound having a superior ACAT-inhibitory activity and/or anti-oxidation action, particularly, novel compound represented by the formula (I) (wherein each symbol is as described in the specification) and a pharmaceutically acceptable salt thereof.

Spiro derivatives as lipoxygenase inhibitors

The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful

ipso Nitration. XXIV. Nitration of 2-methylphenols. Formation and rearrangement of 6-methyl-6-nitrocyclohexa-2,4-dienones

Nitration of o-cresol and some mono-, di-, and trimethyl derivatives in acetic anhydride at -60 deg C gives 6-methyl-6-nitrocyclohexa-2,4-dienones.The dienones are more labile than the isomeric 4-methyl-4-nitrocyclohexa-2,5-dienones and, if the 2-position of the dienone is not blocked, undergo regiospecific rearrangement to 6-nitro-o-cresols. 2,3,6-Trimethyl- and 2,3,5,6-tetramethylphenol also give a 2,5-dienone with nitro attached to a secondary carbon.