92897-11-5Relevant academic research and scientific papers
Dynamic thiol exchange with β-sulfidor-α,β-unsaturated carbonyl compounds and dithianes
Joshi, Gururaj,Anslyn, Eric V.
supporting information, p. 4714 - 4717,4 (2012/12/12)
A reversible covalent bond exchange of thiols, β-sulfido-α, β-unsaturated carbonyls, and dithianes has been studied in DMSO and D 2O/DMSO mixtures. The equilibrium between thiols and β-sulfido-α,β-unsaturated carbonyls is obtained within a few hours, while the equilibration starting with the β-dithiane carbonyls and thiols requires a few days. This time scale makes the system ideal for utilization in dynamic combinatorial chemistry.
