929-24-8Relevant academic research and scientific papers
A comparison between the acid-catalysed reactions of some dihydroxamic acids, monohydroxamic acids and desferal
Ghosh, Kallol K.,Patle, Shyam Kumar,Sharma, Pokhraj,Rajput, Surendra Kumar
, p. 283 - 290 (2003)
A kinetic study on the hydrolysis of some dihydroxamic acids HOHNOC-(CH2)n-CONHOH (n = 0, oxalo, [ODHA]; n = 1 malono [MDHA]; and n = 2, succino, [SDHA] dihydroxamic acids) in aqueous mineral acids is reported. A comparison of the kinetic data with those from the hydrolysis of simple monohydroxamic acid, (acetohydroxamic acid [AHA] CH3CONHOH, benzohydroxamic acid [BHA] C6H5CONHOH) and the natural trihydroxamate-based siderophore desferal (DFB) revealed that the hydrolytic stability sequence of the compounds is generally: BHA > ODHA > MDHA > DFB > AHA > SDHA. An excess acidity analysis reveals that the reaction involving a pre-equilibrium protonation was followed by a rate determining A-2 type nucleophilic attack of water molecule on the protonated substrate. An attempt has been made to study protonation equilibria.
Kinetics and mechanism of the hydrolysis of hydroxamate siderophore
Ghosh, Kallol K.,Tamrakar, Pankaj,Thakur, Santosh S.
, p. 185 - 188 (2007/10/03)
A kinetic and product study of hydrolysis of hydroxamate siderophore, i.e. desferal in aqueous hydrochloric acid media (0.029-2.32 mol dm-3) is reported. Solvent isotope, salt, organic solvents, and temperature effects have also been probed. A Cox-Yates excess acidity analysis of the observed pseudo-first order rate constants as a function of acidity indicates an A-2 mechanism.
