929028-89-7Relevant academic research and scientific papers
Core exploration in optimization of chemokine receptor CCR4 antagonists
Purandare, Ashok V.,Wan, Honghe,Somerville, John E.,Burke, Christine,Vaccaro, Wayne,Yang, XiaoXia,McIntyre, Kim W.,Poss, Michael A.
, p. 679 - 682 (2007/10/03)
The design, synthesis, and SAR studies of 'core' variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was e
